Specific terms like “SGLT-2 inhibitors”, “SGLT2i“, “flozins”, “adipocyte”, “adipokines”, “adiponectin”, “leptin”, “ghrelin”, “resistin”, “apelin”, “adipose tissue”, “weight loss”, ”diabetes mellitus type 2”, “heart failure” were selected to be the key words to sift out studies, which might be potentially relevant. The gene discussed is LEP; the disease is diabetes mellitus.