Specific terms like “SGLT-2 inhibitors”, “SGLT2i“, “flozins”, “adipocyte”, “adipokines”, “adiponectin”, “leptin”, “ghrelin”, “resistin”, “apelin”, “adipose tissue”, “weight loss”, ”diabetes mellitus type 2”, “heart failure” were selected to be the key words to sift out studies, which might be potentially relevant. This evidence concerns the gene LEP and type 2 diabetes mellitus.