Moreover, MIF-1 > 520 pg/mL proved to be a significant determinant for low TAPSE (p = 0.041) among other parameters—the upper tertiles of GGT (p = 0.015) and NT-proBNP (p = 0.005)—in Model 2, even after adjusting for various confounders, such as gender, the habit of smoking, comorbidities (chronic obstructive pulmonary disease (COPD), hypertension, coronary artery disease (CAD)) and laboratory parameters (absolute monocyte count, HDL-cholesterol and TSH levels). The gene discussed is NPPB; the disease is chronic obstructive pulmonary disease.