In 2017, Xu et al. reported that UBE2O is highly expressed in normal bone marrow cells but is significantly downregulated in precursor lesions of multiple myeloma (MM), including monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), as well as in MM cells [46]. The gene discussed is UBE2O; the disease is plasma cell myeloma.