AR signaling in neurons is a key driver of PCOS traits and is necessary for the development of ovulatory dysfunction, polycystic ovarian morphology, and metabolic abnormalities in the dihydrotestosterone (DHT)-induced PCOS mouse model [7], indicating that extraovarian AR-mediated mechanisms contribute significantly to PCOS pathology, providing a potential therapeutic target. The gene discussed is AR; the disease is polycystic ovary syndrome.