In this study, we investigated the expression of protein-coding genes in blood samples from AML patients and controls using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases (detailed information is provided in the Methods section), and we subsequently applied the feature selection method of LASSO to select the optimal gene subset for classifying AML patients and controls as well as between a particular FAB subtype and other subtypes of AML. This evidence concerns the gene FANCB and acute myeloid leukemia.