Insulin-like growth factor-1 (IGF-1) is a growth factor and higher levels in the blood are linked to an increased risk of breast cancer and glioma-associated oncogene 1 (GLI1) is a critical transcriptional factor of the sonic hedgehog pathway that is linked with cancer progression and is related to the unfavorable prognosis of breast cancer. This evidence concerns the gene GLI1 and breast carcinoma.