In addition to affecting cell cycle regulation and apoptosis, SFN seems to inhibit critical signaling pathways in OSA by downregulating the PI3K/AKT and MAPK pathways, both of which are frequently overactivated in these cancer cells, by inhibiting the phosphorylation of Akt and ERK, key regulators of cell survival and proliferation, and therefore promoting cell viability and growth [20]. Here, AKT1 is linked to obstructive sleep apnea syndrome.