IGFBP2 and glioblastoma: In inflammatory conditions, high serum IGFBP-2 levels are associated with elevated levels of the cytokine interleukin (IL)-6 [62], another prognostic factor for GBM [63], which negatively regulates serum albumin levels by increasing catabolism and downregulating synthesis in the liver, further worsening the nutritional status of the patient.