On the other hand, the hypothesized secondary iTTP autoantibodies against ADAMTS13 are related to the presence of underlying autoimmune conditions (e.g., systemic lupus erythematosus, Sjogren’s syndrome, and rheumatoid arthritis), infections (e.g., CMV and HIV), hormone fluctuations (e.g., pregnancy), and even medications (e.g., ticlopidine, quinine, simvastatin, trimethoprim, and pegylated interferon) [82]. The gene discussed is ADAMTS13; the disease is infection.