The results also showed that ligand–receptor binding associated with protease inhibition (e.g., TIMP1-EGFR) and anti-inflammatory processes (e.g., ANXA1-FPR1 and IL1RN-IL1R1) was notably absent in various cells in keratoconus, providing deeper insights for diagnosis and treatment. The gene discussed is IL1RN; the disease is keratoconus.