BRCA1 and neoplasm: In a tumor-agnostic cohort study by Zhou and colleagues, those with BRCA1 or BRCA2 alterations had higher median TMB than their wild-type counterparts (24.6 vs. 5.9, p < 0.001) and comprised a higher proportion with high-TMB tumors (defined as the top 10% of TMB in each tumor type).