This category includes angioedema due to the mutation of angiopoietin-1 (HAE-ANGPT1), myoferlin (HAE-MYOF), and heparan sulfate-glucosamine 3-O sulfotransfersase (HAE-HS3ST6), which are structural endothelial proteins that bind kininogen. The gene discussed is ANGPT1; the disease is angioedema.