WT1 and kidney disorder: Despite the distinct effects these syndromes have on the type of WT1 protein produced, recent studies have shown that mutations typically associated with Frasier syndrome may also result in the nephropathy characteristic of Denys–Drash syndrome, and conversely, WT1 mutations characteristic of Denys–Drash syndrome can give rise to the glomerulosclerosis observed in Frasier syndrome [22,23].