For example, the absence of the characteristic triad seen in Denys–Drash syndrome (Wilms tumor, nephropathy, and genitourinary anomalies), Frasier syndrome (46,XY gonadal dysgenesis, renal failure, and gonadoblastoma), or the constellation of findings represented by the WAGR acronym can result in a failure to identify individuals affected by WT1 mutations. This evidence concerns the gene WT1 and Renal insufficiency.