Low-grade inflammation is a hallmark of adult obesity, with adipose tissue depots producing and secreting inflammatory mediators, most frequently IL-6, interleukin-8 (IL-8), interleukin-1 receptor antagonist (IL-1Ra), and TNF-α, among others [31,32,33,34]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.