FZD4 and Familial exudative vitreoretinopathy: FEVR is an inherited disease characterized by poor vascularization of the peripheral retina, retinal neovascularization, subretinal exudates, and RD, and linked to multiple mutations in genes including KIF11, FZD4, TSPAN12, LRP5, NDP, JAG1, ZNF408, and TUBGCP6 [7,8,9,10].