PSEN1 and early-onset autosomal dominant Alzheimer disease: Notably, the Tg2576 line (AβPP Swe × PS1 M146L [83]) exhibits a 5-fold augmentation in Aβ40 and a 14-fold augmentation in Aβ42 production, in addition to the presence of numerous plaques and a range of behavioral, biochemical, and pathological features analogous to those observed in Alzheimer’s disease [84].