These included the PI3K-Akt signaling pathway, protein digestion and absorption, human papillomavirus infection, the AGE-RAGE signaling pathway, the adipocytokine signaling pathway, the AMPK signaling pathway, bile secretion, glycerophospholipid metabolism, and the cAMP signaling pathway related to diabetic complications (see Figure 4C). The gene discussed is PRKAA1; the disease is human papilloma virus infection.