CNS-resident microglia and resident macrophages are activated during MS to produce inflammatory cytokines, chemokines, and neurotoxic products, such as tumor necrosis factor alpha (TNF-α) and reactive nitrogen/oxygen species, which result in the main process of demyelination that leads to its involvement with neurodegeneration, antigen-presenting cells, and debris clearance for the regulation of remyelination [22,25]. Here, TNF is linked to myeloid sarcoma.