In GC, as reported by Na et al., cyclopamine (Cyc), another natural small-molecule antagonist of Hh signalling, can exert anti-tumour effects by sensitising Tumour Necrosis Factor-Related (TNF)-related apoptosis-inducing ligand (TRAIL) resistant GC cells to TRAIL-mediated cell death via regulating stress response [26]. The gene discussed is TNFSF10; the disease is gastric cancer.