Together, these results demonstrate that NKR‐P1A+ and NKR‐P1A‒ NK cells from CMV‐infected individuals are responsive toward cytokines and proliferate equally well in vitro, and that cytokine‐induced NKR‐P1A receptor upregulation is not affected by CMV infection. The gene discussed is KLRB1; the disease is cytomegalovirus infection.