Patients carrying GATOR1 subcomplex mutations are at increased risk of sudden unexpected death in epilepsy (SUDEP), although further studies are required to elucidate whether GATOR1 complex mutations directly influences SUDEP (e.g. through alteration of cardiovascular expression of DEPDC5 and NPRL3) or whether the increased prevalence of SUDEP in GATORopathies simply reflects the severity of the epilepsy expression (174, 178–181). This evidence concerns the gene DEPDC5 and epilepsy.