SP1 and early-onset autosomal dominant Alzheimer disease: KEGG pathway enrichment analysis of these DEGs indicated enrichment in the Sp1 signaling pathway, including a variety of neurodegenerative disorders, such as Parkinson disease, Alzheimer disease, Huntington disease, Spinocerebellar ataxia, etc (Fig. 6C), which suggest that alterations in the transcription factor Sp1 may play a critical role in neurodegenerative disorders.