ADAMDEC1 and cystic fibrosis: These proteins highlight key pathophysiological processes in CF, such as a compensatory response by guanylin (GUCA2A) to restore proper fluid balance in the intestine (Sindic, 2013), increased chronic inflammation and extracellular matrix remodeling by ADAM-like decysin 1 (ADAMDEC1) (Jasso et al, 2022), and compensatory response by fatty acid-binding protein 1 (FABP1) to altered lipid metabolism in the liver (Peretti et al, 2005).