Among the upregulated proteins, ceruloplasmin (CP), an independent predictor of long-term all-cause mortality in patients with heart failure (Hammadah et al, 2014), and thioredoxin (TXN), a redox regulator previously linked to chronic heart failure (Jekell et al, 2004; Sánchez-Villamil et al, 2016), are particularly notable. The gene discussed is CP; the disease is congestive heart failure.