Another pathway of interest that was enriched in the soft matrix grown PDECs was COX2 pathway since earlier studies have linked the COX2-prostaglandin E2 (PGE2) pathway to immune suppression in the tumor immune microenvironment (TIME)38 and to FGF2 expression in endometrial and pancreatic cancer39,40. The gene discussed is PTGS2; the disease is neoplasm.