ADNP and Alzheimer disease: ADNP is tightly associated with synaptic plasticity and neuronal integrity, functioning as a key regulator for cognition.33,34 A gradual decrease in cortical ADNP expression has been previously reported in the FTD mouse model.35 Downregulation of ADNP was similarly reported from a clinical study examining serum collected from symptomatic AD patients, linking decreased ADNP expression to disease progression.36 In the current study, ADNP was identified as one of the top DEGs related to many biological pathways, including memory, synaptic activity, and microtubule bundle formation.