ADNP and Alzheimer disease: Similar to what was observed in PSAPP mice, while a significant decrease in ADNP expression was detected in the hippocampus of both male and female APPKI-Sham mice compared to the WT-Sham group, APPKI-SynCav1 mice exhibited significantly higher ADNP protein expression compared to APPKI-Sham mice, confirming that SynCav1 preserved ADNP expression in an additional AD mouse model.