Compared to the widely used PSAPP mouse model that features overexpression of APP and overproduction of amyloid-β, the APPKI mouse model more closely recapitulates human AD pathology as it expresses physiological level of APP and exhibits aberrant APP processing seen in human patients.18 Utilizing multiple behavioral tests, we assessed the safety and efficacy of SynCav1 therapy on general behavior and cognitive function. This evidence concerns the gene APP and Alzheimer disease.