HBD and neoplasm: For the two survival types, the overlap of differential changes between tumor and the adjacent nontumor tissue consisted of 146 common proteins revealing enrichment of glycolytic enzymes (e.g., GAPDH, ALDOC, ALDO), proteins involved in oxygen transport (e.g. HBD) and enzymes involved in heme biosynthesis (e.g. ALAD, QDPR, UROD, CPOX) (Fig. 2e, f and Supplementary Fig. 4c).