MMP9 and lung cancer: Remarkably, in tumors we observed a strong co-depletion between the active fractions of Plasminogen (PLG) and Fatty Acid Synthase (FASN) and their known interactors related to lung cancer Matrix metallopeptidase-9 (MMP9)57 and Histone-arginine methyltransferase (CARM1)58, respectively (Fig. 5b, left).