We also noted that NUP98 was selected as the top mutated SH genes in KRAS mutated LUAD in TCGA (Supplementary Fig. 9f) and thus we suppose that the lung accumulation of mercury from environmental exposure, together with genetic variants of its protein sequence, most likely could contribute individually or jointly to the loss of NUP98’s proteolytic ability and its tumor suppressor function77,78. The gene discussed is KRAS; the disease is neoplasm.