While some elevated SHs in LUAD tumors to adjacent-tissue displayed specific patterns of catalytic fractions for survival-subtype (e.g., FASN, DPP4, SCPEP1 for long-term survivals), we observed that most enzymes that separated LUAD tumors from matched controls of both subtypes (e.g., Variate 1), showed an overall increased hydrolytic activity in both tumor subtypes compared to adjacent-tissues. This evidence concerns the gene DPP4 and neoplasm.