In Wnk1f/− leukaemia cells, ectopic expression of either constitutively active human OXSR1T185E,S325E or human STK39T233E,S373E, maintained the phosphorylation of S6K1 and 4EBP1 upon OHT-induced Wnk1 deletion (Fig. 5e). Here, RPS6KB1 is linked to leukemia.