为了评估敲除供者T细胞Stat3对GVL效应的影响,设立两组分别回输去除T细胞的骨髓细胞(TCD-BM组)和Stat3敲除T细胞(Stat3-KO组),移植时通过尾静脉注射接种1×104个ALL/Luc细胞,构建GVL小鼠模型。TCD-BM组的ALL/Luc细胞迅速生长,20 d内均死亡。而Stat3-KO组有80%小鼠无肿瘤存活超过100 d(P<0.05,图1D、E)。. This evidence concerns the gene STAT3 and acute lymphoblastic leukemia.