Lipedema TSAT showed reduced expression of genes (i) VEGFC, vascular endothelial growth factor (VEGF)–C, and its cognate receptor FLT4 (protein is VEGFR‐3), which have canonical roles in blood and lymphatic vessel proliferation and function [69, 70, 71]; (ii) CLD11, claudin 11, which regulates lymphatic valve development [72]; (iii) SOX17, which is important for endothelial regeneration following injury [73, 74]; (iv) THBS4, thrombospondin 4, which regulates endothelial ECM interaction [75]; and (vi) ANG, angiogenin, which regulates angiogenesis [76]. This evidence concerns the gene ANG and Lipedema.