Eliminating or reducing the activity of HUWE1 itself, which in turn reduces WNT/CTNNB1 signaling in WT HAP1-7TGP, CSNK1A1KO and CTNNB1ST-A cells, is unlikely to be a viable therapeutic strategy due to the multiple roles of HUWE1 on cell physiology, including tumor suppressor functions [37]. Here, HUWE1 is linked to neoplasm.