The results observed that in most tumors, immune checkpoint genes were significantly positively correlated with NR2F6 expression, while in some cancers, such as CHOL, KIPAN, BRCA, TGCT, PAAD, most immune checkpoint genes were significantly negatively correlated with NR2F6 expression, especially genes such as CTLA4, SLAMF7, HAVCR2 and TIGIT. The gene discussed is NR2F6; the disease is cancer.