Immune cell infiltration analysis based on TIMER algorithm found that the expression of NR2F6 was significantly negatively associated with T cell infiltration in most cancers, while that the high NR2F6 expression was associated with worse prognosis, suggesting that targeted inhibition of NR2F6 expression level in pancancer may induce increased T cell infiltration, thus enabling tumor benefit in immunotherapy. This evidence concerns the gene NR2F6 and neoplasm.