According to the pancancer analysis, we found that the overall survival of children in the NR2F6 high expression group was worse than that of the NR2F6 low expression group; in addition, multivariate Cox regression analysis confirmed that NR2F6 expression level, COG risk and MKI were independent risk factors affecting OS in NB children, emphasizing the importance of NR2F6 for the evaluation of prognosis of NB children. Here, NR2F6 is linked to neuroblastoma.