Analysis of mRNA expression profiles and protein expression levels revealed significant up-regulation in 25 cancer tissues and significant down-regulation in low-grade glioma (LGG), papillary cell carcinoma of the kidney (KIPAN), and clear cell carcinoma of the kidney (KIRC) tissues, suggesting distinct roles for NR2F6 in the development of different cancers. This evidence concerns the gene NR2F6 and central nervous system cancer.