TNFRSF4 and neuroblastoma: However, in NB, NR2F6 expression was significantly and positively correlated with the expression of immune checkpoint genes such as TNFSF9, HMGB 1, TNFRSF4, TNF, PRF 1, LAG 3, IDO 1, VE GF B, CD276, VE GF A, and AL12A (Fig 4D).