In line with the Reactome enrichment of the rhythmic genes, proteins and their activated forms in seven key cancer pathways (apoptosis, cell cycle, epithelial-mesenchymal transition, MAPK, PI3K/AKT, metabolism and receptor tyrosine kinase) were rhythmic in almost all ACs, which is also consistent with insights from gene expression signatures [45]. This evidence concerns the gene AKT1 and cancer.