PIK3R4 and ovarian carcinoma: Subsequently, we identified ten genes (COL6A3, SPI1, HSF1, CD3E, PIK3R4, MZB1, FERMT3, GZMA, PSMB9 and RSF1) which could serve as independent prognostic factors for patients with advanced ovarian cancer (P < 0.05) (Fig 2B).