While m6A modification of IFN-β mRNA suppresses antiviral responses during viral infection (Rubio et al., 2018; Winkler et al., 2019), this modification also paradoxically enhances antiviral response through different regulation of ISG transcripts, such as enhancing translation of IFIT1 (McFadden et al., 2021) and prolonging STAT1 and IRF1 mRNAs stability (Wang et al., 2020a), demonstrating the complexity of m6A in immune modulation. This evidence concerns the gene IFNB1 and viral infectious disease.