INS and obesity due to melanocortin 4 receptor deficiency: Comparable glucose intolerance and serum lipid levels in Cnot4 Het mice and WT mice but resistance to obesity in Cnot4 Het mice is intriguing, whereas these phenotypes are partially similar to PPARγ heterozygous knockout (PPARγ+/–) mice, which exhibited resistance to HFD-induced obesity and increased sensitivity to insulin but little or no improvement in glucose intolerance [34].