Comparable glucose intolerance and serum lipid levels in Cnot4 Het mice and WT mice but resistance to obesity in Cnot4 Het mice is intriguing, whereas these phenotypes are partially similar to PPARγ heterozygous knockout (PPARγ+/–) mice, which exhibited resistance to HFD-induced obesity and increased sensitivity to insulin but little or no improvement in glucose intolerance [34]. This evidence concerns the gene CNOT4 and obesity due to melanocortin 4 receptor deficiency.