The results showed that the TREM2/Syk/PI3K/AKT/mTOR pathway played an important role in the Aβ-induced AD model, and HAN enhanced the function of the TREM2/Syk/PI3K/AKT/mTOR signaling pathway in Aβ-induced HMC3 cells. Here, PIK3CA is linked to Alzheimer disease.