Alternatively, infection performed in KCs isolated from ApoE-knockout (KO)-mice (Apoe−/−) with inherent diet-induced hyperlipidemia (Hinder et al., 2013), resulted in significant increase in amastigote load as compared to wild-type C57BL/6-infected-KCs, only for LD-R-infection, with LD-S-infection resulting in comparable amastigote load (Figure 2Bi, ii). The gene discussed is APOE; the disease is infection.