Similarly, stimulation of LD-infected splenocytes obtained from LD-S and LD-R-infected Apoe−/− mice with specific soluble Leishmamia antigens (SLA) of LD-S or LD-R also confirmed this restricted IFN-γ response to LD-R-infection (Figure 7Bii), thus suggesting that although LD-R-infection results in increased accumulation of lipids in host MΦs, it elicits a suppressed inflammatory response as compared to LD-S. Here, APOE is linked to infection.