Interestingly, while, western blot analysis revealed minimal expression of LAMP-1 in response to LD-S-infection at 4 hr p.i., which increased considerably as the infection progressed (Figure 5Ci), however, a considerable amount of LAMP-1 expression was observed for LD-R-infected-KCs from 4 hr p.i., which also increased as infection progresses (Figure 5Cii), indicating that a higher fusion of LDL-vesicles in LD-R-PV may be accompanied by increased lysosomal biogenesis required for degrading LDL into cholesterol. The gene discussed is TBCE; the disease is infection.