CCR2 and Candidiasis, Invasive: WT mice of both genotypes were able to clear the fungus from the brain and kidney when treated with liposome vehicle alone, but they had detectable fungal burden in both tissues when treated with clodronate (Figure 8 and Supplemental Figure 9); this finding is consistent with that previously reported using clodronate-based depletion in a high-dose model (14) and confirms our Ccr2–/– data on the importance of mononuclear phagocytes in this chronic invasive candidiasis model.