CARD9 and Candidiasis, Invasive: However, since invasive candidiasis associated with human CARD9 deficiency is often chronic in nature, with a median age at onset of 17.5 years (range, 3.5–58 years) (1, 16), and is not typically accompanied by fulminant sepsis, the relevance of these mouse models to understanding the chronic features of the human disease remains unclear.