Fulminant morbidity and mortality, as well as the disseminated (multiorgan) nature of candidiasis observed in the CARD9-deficient strains using the high-dose approach, poorly models the fungal disease in human CARD9 deficiency, where disease can progress over years with predominant CNS involvement and pauci-involvement of other organs (1, 3, 4). The gene discussed is CARD9; the disease is Candidiasis, Invasive.