To understand how the p.Y91H mutation in CARD9 predisposes to invasive candidiasis, we used CRISPR/Cas9 to knock in the c.T271C mutation into C57BL/6N (B6N) mice (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.176676DS1). This evidence concerns the gene CARD9 and Candidiasis, Invasive.