CCR2 and infection: As early monocyte responses in the brain were demonstrated to be important in the high-dose model of candidiasis using Ccr2–/– mice, which lack circulating monocytes at steady state and show significant delays in monocyte egress from the bone marrow during infection (24), we assessed the importance of our observed monocyte response by evaluating Ccr2–/– mice infected with low-dose C. albicans.