CARD9 and fungal infectious disease: Furthermore, eosinophilic infiltration of CNS tissue can be seen in some patients with CARD9 deficiency, as it can in other patients who do not have CARD9 deficiency but who have chronic fungal infections, and indeed 3 of the Y91HKI mice analyzed for flow cytometry showed eosinophil recruitment to the brain by day 4 p.i. (Supplemental Figure 8).