Overall, bariatric surgery seems to improve the cytokine profile by lowering chronically elevated cytokine levels [10–13], such as interleukin-6 (IL-6), but to our knowledge only one study has comprehensively investigated the cytokine profile of 76 markers in obesity and the effects of bariatric surgery [14]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.