Akt signaling pathway has been verified to play a role in GO adipogenesis, cell migration, cell proliferation and inflammation in several studies, and these studies pointed to phosphorylation of Akt at serine 473 (phospho-Akt, pAkt) was elevated in OFs in GO, which was considered to be an important pathogenesis of GO [28–32]. The gene discussed is AKT1; the disease is geroderma osteodysplastica.