CXCL8 and Alzheimer disease: As Avène thermal water profoundly reduces the colonization of pathogenic bacteria such as Staphylococcus aureus in AD lesions, the inhibition of inflammatory interleukins (IL-8) (responsible for AD aggression and the regulation of the enzymatic activities of proteases, b-glucocerebrosidases, and phospholipase A2 to restore the AD rupture skin barrier and ameliorate AD symptoms, resulting in soothing and antipruritic effects) could be responsible for its therapeutic effects.