PRL and atopic eczema: On the other hand, the thermal effect of thermal water also play major role in treating skin diseases by increasing production of cortisol, β-endorphins, prolactin, norephinephrine, adrenocorticotropic hormone and prolactin and also decrease basophils degranulation in patients of atopic dermatitis (Borroni et al. 2013; Sacerdote et al. 2002).