Extensive homeostatic regulation of Kv2.1 gating maintains neuronal excitability Misonou et al., 2006; for example, ischemia (Misonou et al., 2005; Aras et al., 2009), glutamate (Misonou et al., 2008), phosphorylation (Murakoshi et al., 1997), SUMOylation (Plant et al., 2011), and AMIGO auxiliary subunits (Peltola et al., 2011; Maverick et al., 2021) all alter Kv2 gating. The gene discussed is AMIGO1; the disease is ischemia.