By using some natural drugs such as Dendrobium officinale (DOE) on myocardial fibrosis in mice, DOE can suppress fibrosis by inhibiting EMT and EMT-related signaling molecules (such as TGF-β1, p-JNK, Twist, Snail1, Vimentin, etc.)[34]. The gene discussed is TWIST1; the disease is Myocardial fibrosis.