MAPT and Cognitive impairment: Likewise, in primary tauopathies such as Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), and Frontotemporal Dementia with Parkinsonism (FTDP-17), the involvement of different Tau isoforms—particularly 4R—has been identified, with pathological accumulations in specific brain regions and in glial cells, resulting in particular symptom profiles including movement disorders, cognitive impairment, and language deficits.