Gene alteration and aging with telomere attrition: mutations or variants in genes, for example, the gene for surfactant protein A (SFTPA) inducing tumor growth factor beta (TGFβ) secretion, squamous cell carcinoma antigen (SCCA), a serine protease inhibitor typically expressed by dysplastic/neoplastic cells of epithelial origin, abnormal telomere shortening (such as h-TERT or h-TERC mutation) and cellular senescence were found both in lung cancer and ILDs [26,27,28,29]. The gene discussed is SFTPA2; the disease is lung cancer.