Analysis of the primary lung carcinomas showed the following mutations: EGFR (six cases, five in late metastases: one exon 19 del and three L858R; one early metastasis: exon 19 del), KRAS (three cases, two in late metastases: G12D, G12V; one in early metastasis: G12C), and ERBB2 (one case with late metastasis, S310F). This evidence concerns the gene KRAS and lung carcinoma.