Regarding prognosis and response to treatment, in the largest study to date, Cawthorn et al. [39] analyzed a tissue microarray consisting of 990 early breast cancer cases (590 stage I and 400 stage II) and found that high expression levels of Decorin and Endoplasmin (HSP90B1) were associated with increased metastasis-poorer survival and may guide the use of hormonal therapy. The gene discussed is DCN; the disease is breast carcinoma.