CD163+ macrophages, often associated with an M2-like phenotype, contribute to immunosuppression, angiogenesis, and metastasis in various sarcoma subtypes; these macrophages secrete key cytokines, such as IL-6 and CXCL2, which are pivotal in enhancing tumor cell proliferation and survival via pathways such as STAT3 activation. Here, STAT3 is linked to neoplasm.