It is possible to hypothesize that, at the basis of the OD in CRSwNP and the olfactory improvement following treatment with Dupilumab, there are immunological mechanisms with direct or indirect involvement of interleukins (ILs) and, in particular, IL-4, IL-5, IL- 13, and eosin-ophiles [14]. Here, IL5 is linked to chronic rhinosinusitis with nasal polyps.