Numerous acquired conditions, including diabetes, obstructive sleep apnea syndrome (OSAS), and obesity, as well as genetic disorders such as atrial natriuretic peptide (NAPP) mutations and muscular dystrophies, are linked to structural changes in the atrial wall and conduction system, which ultimately may eventually result in AF [3]. This evidence concerns the gene NPPA and obesity due to melanocortin 4 receptor deficiency.